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Year : 2015  |  Volume : 1  |  Issue : 3  |  Page : 80-93

Recent Progress in Genetic and Epigenetic Profile of Diffuse Gastric Cancer

1 Division of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China
2 Division of Oncology; Cancer Research Institute of Central South University, Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China

Correspondence Address:
Bin Li
Division of Oncology, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha 410008, Hunan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2395-3977.159532

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Gastric cancer (GC) is the second leading cause of death from cancer worldwide, with 5-year survival rate for about 20% of the affected individuals. Although there is a decrease in the intestinal-type GC (IGC), the incidence of diffuse-type is still increasing, and its progression is notoriously aggressive. Clinically, diffuse GCs (DGCs) propensity for invasion into adjacent tissue, with prominent stromal induction, which presents with linitis plastica, peritoneal implantation and remote metastasis, ends up in dismal prognosis, and translates into poor quality of life. So far, a few molecularly targeted drugs, including HER2 antagonists, have been developed against GC, but most in treating IGC. Thus, DGC constitutes a poor prognosis subgroup of GC with no known promising therapies. Recent genomic characterization of GC by whole-genome and whole-exome sequencing showed that a large number of known cancer-related genes are frequently mutated in gastric malignancies. In the light of this discovery, we did an extensive review of recent literature on progress in genetic and epigenetic profile of DGC. The summary of which makes us believe that it is possible to develop novel therapeutic strategies against this otherwise devastating disease that undergo massive invasion and metastasis.

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