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ORIGINAL ARTICLE
Year : 2015  |  Volume : 1  |  Issue : 4  |  Page : 111-114

Expression Characteristics of miR-10b in Nasopharyngeal Carcinoma


Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

Correspondence Address:
Dr. Gang Li
Department of Otolaryngology, Head and Neck Surgery, Nanfang Hospital, 1838 Guangzhou Dadao Bei, Southern Medical University, Guangzhou 510515, Guangdong
China
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Source of Support: This study was supported in part by grants from the National Natural Science Foundation of China to Gang Li (No. 81472534), Conflict of Interest: None


DOI: 10.4103/2395-3977.163801

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Aim: Nasopharyngeal carcinoma (NPC) is a highly malignant neoplasm characterized with aggressive local invasion and strong tendency of distant metastasis. MicroRNAs (miRNAs) are small noncoding RNAs that play a critical role in the pathogenesis of various malignant tumors. Our previous study aims to explore miRNAs' expression characteristics in NPC tissue, which is barely unknown. Methods: A total of 45 NPC samples (26 metastatic and 19 nonmetastatic) and 16 chronic nasopharyngitis samples were analyzed. miR-10b level was determined by in situ hybridization using digoxigenin-labeled locked nucleic acid-based probe, and latent membrane protein-1 (LMP-1) expression were detected by immunohistochemistry. Results: We show that miR-10b is differentially expressed in NPC tissues. Furthermore, we correlate the expression level of miR-10b with Epstein-Barr virus encoding LMP-1. Overexpression of miR-10b is also found to relate with the clinical phases of NPC. Conclusion: These findings strongly suggest that miR-10b plays an important role in the NPC development.


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