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Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 29-32

CD24 as a Molecular Marker in Ovarian Cancer: A Literature Review

1 Department of Gynecology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China
2 Department of Gynecologic Oncology, Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Correspondence Address:
Xiaofeng Zhao
Department of Gynecology, Zhejiang Provincial People's Hospital, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2395-3977.177563

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Ovarian cancer is the most lethal gynecologic cancer, with a mortality rate of > 60%. Cancer stem cell (CSC) hypothesis offers an attractive explanation of chemoresistance, metastasis, etc., associated with the disease. However, there are still controversy and limitation in defining the CSC markers. CD24 is a mucin-type glycosyl-phosphatidylinositol-linked glycoprotein, expressed on the surface of cells, which serves as a normal receptor for P-selectin and is found involved in molecular adhesion and metastatic tumor spread. Expression rate of CD24 has been associated with progression of various cancers and poor survival rates. In this review, the function of CD24 in ovarian cancer, especially in ovarian CSC system, was discussed in an effort to broaden the interpretation of potential mechanism.

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