• Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW
Year : 2016  |  Volume : 2  |  Issue : 2  |  Page : 55-60

The Potential of Wnt Signaling Pathway in Cancer: A Focus on Breast Cancer


Department of Cancer Biology, Division of Molecular Endocrinology, Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, Gujarat, India

Correspondence Address:
Dr. Nandita R Ghosh
Department of Cancer Biology, Division of Molecular Endocrinology, Gujarat Cancer & Research Institute, NCH Compound, Asarwa, Ahmedabad 380016, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-3977.181437

Rights and Permissions

Cancer development and progression as well as tumor recurrence are largely due to the presence of cancer stem cells (CSCs) that are maintained through various pathways. Wnt/β-catenin signaling is the fundamental pathway, which when deregulated leads to tumor development by sustaining CSC population. Along with the upregulation of its various components, Wnt pathway is highly active in cancer cells resulting in increased expression of the target genes. In breast cancer condition, convincing results are available wherein the Wnt pathway activation in breast cancer cells increases the cell motility while its blockade suppresses their aggressive behavior in vitro. Further, numerous reports on breast cancer patients have documented the importance of activation of Wnt pathway and its components to an extent that the regulation can be exploited therapeutically with promising results. In addition, recent research has laid emphasis on the significance of Wnt pathway in the triple-negative breast cancer, a molecular subtype of breast cancer, which lacks targeted therapy till date. Hence, understanding of Wnt signaling and its targeting to treat such patients can be an assuring approach.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4092    
    Printed145    
    Emailed0    
    PDF Downloaded795    
    Comments [Add]    
    Cited by others 9    

Recommend this journal