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MINI REVIEW
Year : 2017  |  Volume : 3  |  Issue : 1  |  Page : 34-38

Stem cell-based approach in diabetes and pancreatic cancer management


1 Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
2 Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA, USA

Correspondence Address:
Demeng Chen
Division of Oral Biology and Medicine, UCLA School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095-1668
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-3977.200857

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Stem cell-mediated therapy is a promising strategy for treating pancreatic diseases such as Type-1 diabetes (T1D) and pancreatic cancers. Although islet transplantation has been reported to be an effective diabetes therapy, its worldwide application is extremely limited due to the shortage of donor islets and immune rejection problems. Stem cell-based approach for islet neogenesis in vivo could provide a promising alternative source of islets for treating diabetes. On the other hand, targeting the cancer stem cells could be very effective for the treatment of pancreatic cancers. In this review, we focused on the present progress in the field of adult pancreatic stem cells, stem cell-mediated strategies for treating T1D, and pancreatic cancer stem cells, while discussing of the possible challenges involved in them.


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