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MINI REVIEW
Year : 2017  |  Volume : 3  |  Issue : 3  |  Page : 87-95

Stemness-related markers in cancer


1 Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
2 Department of Medical Oncology, Dana-Farber Institute and Harvard Medical School, Boston, MA, USA

Correspondence Address:
Dr. Xun Zhang
Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, BUL457, Boston, MA 02114
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ctm.ctm_69_16

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Cancer stem cells (CSCs), with their self-renewal ability and multilineage differentiation potential, are a critical subpopulation of tumor cells that can drive tumor initiation, growth, and resistance to therapy. Like embryonic and adult stem cells, CSCs express markers that are not expressed in normal somatic cells and are thus thought to contribute toward a “stemness” phenotype. This review summarizes the current knowledge of stemness-related markers in human cancers, with a particular focus on important transcription factors, protein surface markers, and signaling pathways.


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