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Year : 2017  |  Volume : 3  |  Issue : 5  |  Page : 181-184

The significance of nuclear factor-kappa B signaling pathway in glioma: A review

1 Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
2 Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Correspondence Address:
Yanyang Tu
Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an 710038, Shaanxi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ctm.ctm_48_16

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In recent years, the research on the regulation of nuclear factor kappa B (NF-κB) signaling pathway in tumor cell apoptosis and proliferation is a hot topic. It has been reported that activated NF-κB pathway exerts antiapoptotic effect by inducing antiapoptotic and cell proliferation-related target gene expression, including the Bcl-2 family, survivin, COX-2, Cyclin Dl, and epidermal growth factor receptor, eventually leading to accelerated cell cycle progression and enhanced antiapoptotic and proliferation ability of tumor cells. However, the underlying specific mechanism has not been fully determined. Inhibiting the activation of NF-κB signaling pathway to promote the apoptosis is the topic of research on treating several conditions such as inflammation, immunity, and tumor. In this paper, the correlation between NF-κB signaling pathway and apoptosis of glioma cells is reviewed.

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