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ORIGINAL ARTICLE
Year : 2017  |  Volume : 3  |  Issue : 6  |  Page : 194-199

The producing capabilities of Interferon-γ and Interleukin-10 of spleen cells in primary and metastasized oral squamous cell carcinoma cells-implanted mice


1 Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, Gifu; Department of Anesthesiology, Division of General Medicine, Chemistry Laboratory, Gifu, Japan
2 Department of Management and Information Studies, Asahi University School of Business Administration, Gifu, Japan
3 Department of Oral Biochemistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, Gifu, Japan
4 Department of Oral and Maxillofacial Surgery, Division of Reparative and Regenerative Medicine, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
5 Department of Anesthesiology, Division of General Medicine, Chemistry Laboratory, Asahi University School of Dentistry, Gifu, Japan
6 Department of Oral and Maxillofacial Surgery, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry, Gifu, Japan

Correspondence Address:
Masako Mizuno-Kamiya
Department of Management and Information Studies, Asahi University School of Business Administration, 1851 Hozumi, Mizuho, Gifu 501-0296
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ctm.ctm_30_17

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Aim: The aim of this study is to compare the immunomodulatory effects exerted by primary versus metastasized oral squamous cell carcinoma (OSCC) cells. Methods: Mouse OSCC cell line Sq-1979, 233 cells established from implanted Sq-1979 cells, and L cells established from the metastasized lymph node tissues of Sq-1979-implanted mice were subcutaneously inoculated into the later abdominal area of syngeneic C3H mice. The producing capabilities of interferon (IFN)-γ, a Th1 cytokine, and interleukin (IL)-10, a Th2 cytokine, by anti-CD3 antibody-stimulated spleen cells were investigated in tumor bearing-mice. Results: The quantity of IFN-γ produced by stimulated spleen cells was significantly suppressed in the mice implanted with Sq-1979, 233, and L cells. Conversely, the production of IL-10 was significantly elevated in Sq-1979 and 233 cell-implanted mice while markedly suppressed in L cell-implanted mice. Conclusion: Our results suggest that the metastasized L cells have acquired differential immunomodulatory functions compared to the original Sq-1979 and primary 233 cells.


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