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REVIEW
Year : 2018  |  Volume : 4  |  Issue : 2  |  Page : 59-63

The mechanism of BMI1 in regulating cancer stemness maintenance, metastasis, chemo- and radiation resistance


Department of Experimental Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, Shaanxi, China

Correspondence Address:
Dr. Yanyang Tu
Department of Experimental Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, Shaanxi
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ctm.ctm_7_18

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BMI1 is involved in the occurrence and development of many types of cancer through a variety of signaling pathways. BMI1, which is overexpressed in cancer, is often associated with chemo- and radiation resistance and poor prognosis in cancer patients. This article reviews the current understanding of the mechanism of BMI1 in maintaining tumor stemness, promoting metastasis, and inducing chemo- and radiation resistance, aiming at providing updated information supportive of targeting BMI1 in cancer treatment.


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