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MINI REVIEW
Year : 2018  |  Volume : 4  |  Issue : 6  |  Page : 163-166

Novel insights into the role of bacterial gut microbiota in hepatocellular carcinoma


1 Department of Biliary- Surgery, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China
2 Department of Traditional Chinese Medicine and Chemical Drug, Lanzhou Institutes for Food and Drug Control, Lanzhou, Gansu, China
3 Laboratory Animal Center, Sun Yat-Sen University, Guangzhou, Guangdong, China
4 Boji Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China

Correspondence Address:
Dr. Ruiming Chang
Boji Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yan Jiang West Road, Guangzhou 510120, Guangdong
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ctm.ctm_8_18

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Hepatocellular carcinoma (HCC) mostly develops in patients with chronic liver disease, driven by a vicious cycle of liver injury, inflammation, and regeneration. Increasing evidence points to the influence of bacterial gut microbiota influence on chronic liver disease and the development of HCC. We will review how bacterial gut microbiota contributes to HCC and relevant therapeutic strategies, focusing on alterations of the bacterial gut microbiota at different disease stages and mechanisms by which it contributes to disease progression and HCC development in different types of liver diseases.


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