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CASE REPORT
Year : 2020  |  Volume : 6  |  Issue : 1  |  Page : 21-23

Best-match blood transfusion in pediatric patients with mixed autoantibodies


1 Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
2 Department of Transfusion Medicine, SCB Medical College, Cuttack, Odisha, India
3 Department of Clinical Hematology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. Debasish Mishra
Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ctm.ctm_27_19

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Finding matched blood in autoimmune hemolytic anemic (AIHA) patients is extremely difficult due to autoantibodies. Generally, these antibodies directed against antigens of high prevalence. It is essential for transfusion purposes to provide blood without alloantibodies. We report three cases of mixed AIHA in children. Mixed AIHA may present with blood group discrepancy, as well as incompatibility may possess difficult situation for transfusion laboratory to provide blood units to patients. The patient must be transfused cautiously with least-incompatible, ABO and Rh/ Kell phenotype-matched packed red blood cells slowly under strict supervision and steroid cover.


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