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  Indian J Med Microbiol
 

Figure 1: Synergistic effect of MN58b and TRAIL combinatorial treatment. (a) Cell viability after 24 h and exposure to TRAIL (left) or 48 h to MN58b (right). (b and c) Effect of combinatorial treatment of TRAIL and MN58b following simultaneous or sequential schedules. Combination index is indicated. (d) In vivo cooperation of MN58b and TRAIL in nude mice inoculated with DLD-1 or SW620 xenografts. Data shown are mean ± standard error (n = 20); asterisk denotes statistically significant differences between cells cotreated with TRAIL and MN58b, versus control or single-agent treated cells (P < 0.05). TRAIL: Tumor necrosis factor-related apoptosis inducing ligand

Figure 1: Synergistic effect of MN58b and TRAIL combinatorial treatment. (a) Cell viability after 24 h and exposure to TRAIL (left) or 48 h to MN58b (right). (b and c) Effect of combinatorial treatment of TRAIL and MN58b following simultaneous or sequential schedules. Combination index is indicated. (d) <i>In vivo</i> cooperation of MN58b and TRAIL in nude mice inoculated with DLD-1 or SW620 xenografts. Data shown are mean ± standard error (<i>n</i> = 20); asterisk denotes statistically significant differences between cells cotreated with TRAIL and MN58b, versus control or single-agent treated cells (<i>P</i> < 0.05). TRAIL: Tumor necrosis factor-related apoptosis inducing ligand