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  Indian J Med Microbiol
 

Figure 7: Putative mechanism of action of ChoKα inhibitors for the sensitization of TRAIL resistant cells. Based on the result shown, sensitivity to TRAIL achieved by MN58b treatment is due to an increase in DR5 expression. MN58b could mediate this effect by upregulation of CHOP. TRAIL: Tumor necrosis factor-related apoptosis inducing ligand

Figure 7: Putative mechanism of action of ChoKα inhibitors for the sensitization of TRAIL resistant cells. Based on the result shown, sensitivity to TRAIL achieved by MN58b treatment is due to an increase in DR5 expression. MN58b could mediate this effect by upregulation of CHOP. TRAIL: Tumor necrosis factor-related apoptosis inducing ligand