March-April 2017| Vol 3| Issue 2
Mutation detection with a liquid biopsy 96 mutation assay in cancer patients and healthy donors
Aaron Yun Chen, Glenn D Braunstein, Megan S Anselmo, Jair A Jaboni, Fernando Troy Viloria, Julie A Neidich, Xiang Li, Anja Kammesheidt
Aim: Detection of circulating tumor DNA (ctDNA) holds promise as an adjunct to traditional cancer screening methods. To determine the sensitivity and specificity of ctDNA measurements, levels w...
The application of estrogen receptor-1 mutations' detection through circulating tumor dna in breast cancer
Binliang Liu, Yalan Yang, Zongbi Yi, Xiuwen Guan, Fei Ma
Breast cancer is the most common cancer in women worldwide. Endocrine therapy is the cornerstone of treatment for patients with hormone receptor-positive advanced breast cancer. Unfortunately, althoug...
Circulating micrornas and long noncoding rnas: Liquid biomarkers in thoracic cancers
Pablo Reclusa, Anna Valentino, Rafael Sirera, Martin Frederik Dietrich, Luis Estuardo Raez, Christian Rolfo
Thoracic cancers are the leading causes of cancer-related deaths worldwide. Recent advances in genome and transcriptome analysis have allowed for the identification of numerous classes of noncoding RN...
Exosomes biology: Function and clinical implications in lung cancer
Martin Frederik Dietrich, Christian Rolfo, Pablo Reclusa, Marco Giallombardo, Anna Valentino, Luis E Raez
Lung cancer is the most common malignancy in the United States, totaling 225,000 cases per year. In recent years, several new treatment options have become available based on the molecular and cellula...
Circulating tumor DNA: A potential biomarker from solid tumors' monitor to anticancer therapies
Ting Chen, Rongzhang He, Xinglin Hu, Weihao Luo, Zheng Hu, Jia Li, Lili Duan, Yali Xie, Wenna Luo, Tan Tan, Di-Xian Luo
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Circulating tumor DNA (ctDNA) in the peripheral blood is a liquid biopsy that contains representative tumor information including gene mutations. ctDNA is a promising new avenue for real-time monitori...
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