March-April 2018| Vol 4| Issue 2
Panobinostat and its combination with 3-deazaneplanocin-A induce apoptosis and inhibit In vitro tumorigenesis and metastasis in GOS-3 glioblastoma cell lines
Javier de la Rosa, Alejandro Urdiciain, Juan Jesús Aznar-Morales, Bárbara Meléndez, Juan A Rey, Miguel A Idoate, Javier S Castresana
Aim: Glioblastoma is the most malignant primary brain tumor. The treatment consists of surgery, with or without radiotherapy, and temozolomide, with a life expectancy of 12–15 months af...
Cancer stem-like cells have cisplatin resistance and miR-93 regulate p21 expression in breast cancer
Akiko Sasaki, Yuko Tsunoda, Kanji Furuya, Hideto Oyamada, Mayumi Tsuji, Yuko Udaka, Masahiro Hosonuma, Haruna Shirako, Nana Ichimura, Yuji Kiuchi
Aim: This study aims to examine the role of microRNAs (miRNAs) in regulating the expression of p21, a cyclin-dependent kinase inhibitor, and in inducing resistance to cisplatin, an anticancer...
The contribution of hexokinase 2 in glioma
Hui Liu, Hongwei Yang, Xin Wang, Yanyang Tu
Glioma is the most frequent malignant neoplasm of the central nervous system with high recurrence and extremely poor prognosis. Hexokinase 2 (HK2) is the key enzyme in Warburg effect that has been p...
The mechanism of BMI1 in regulating cancer stemness maintenance, metastasis, chemo- and radiation resistance
Xiaoshan Xu, Zhen Wang, Nan Liu, Pengxing Zhang, Hui Liu, Jing Qi, Yanyang Tu
BMI1 is involved in the occurrence and development of many types of cancer through a variety of signaling pathways. BMI1, which is overexpressed in cancer, is often associated with chemo- and radiat...
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