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Current Issue

July-August 2017| Vol 3| Issue 4

Original Article

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models
Jeremy A Hengst, Taryn E Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su-Fern Tan, Laura M Geffert, Todd E Fox, Arun K Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P Loughran, Robert F Paulson, David F Claxton, Hong-Gang Wang, Jong K Yun

Aim: To further characterize the selectivity, mechanism of action, and therapeutic efficacy of the novel small molecule inhibitor, SKI-178. Methods: We used the state-of-the-art cellula...

Original Article

A T-cell engager-armed oncolytic vaccinia virus to target the tumor stroma
Feng Yu, Bangxing Hong, Xiao-Tong Song

Aim: Cancer-associated fibroblasts (CAFs) are the key cellular components of the tumor stroma. CAFs express fibroblast activation protein (FAP) and FAP-targeted immunotherapies have shown poten...

Original Article

Real-world experience with abiraterone in metastatic castration-resistant prostate cancer
Yasar Ahmed, Nemer Osman, Rizwan Sheikh, Sarah Picardo, Geoffrey Watson

Aim: To evaluate abiraterone in patients with metastatic castration-resistant prostate cancer (mCRPC). Methods: This is a multicenter retrospective analysis, involving 44 consecutive ab...

Short Communication

Combination of Interleukin-11Rα chimeric antigen receptor T-cells and programmed death-1 blockade as an approach to targeting osteosarcoma cells In vitro
Hatel Rana Moonat, Gangxiong Huang, Pooja Dhupkar, Keri Schadler, Nancy Gordon, Eugenie Kleinerman

Aim: To test whether combining interleukin (IL)-11Rα chimeric antigen receptor (CAR) T-cells with an anti-programmed death (PD-1) antibody (an immune checkpoint inhibitor) is an effective ...


Efficacy and safety of paclitaxel-based therapy and nonpaclitaxel-based therapy in advanced gastric cancer
Tongwei Wu, Xiao Yang, Min An, Wenqin Luo, Danxian Cai, Xiaolong Qi

Aim: To compare the efficacy and safety of paclitaxel-based therapy versus nonpaclitaxel-based therapy in patients with advanced gastric cancer (AGC). Methods: An adequate literature se...

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The journal is indexed with, or included in, the following:
DOAJ, Index Copernicus

Cancer Translational Medicine is an open-access and peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s free full text is available online at http://www.cancertm.com

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