January-February 2018| Vol 4| Issue 1
I-Kappa-B kinase-epsilon activates nuclear factor-kappa B and STAT5B and supports glioblastoma growth but amlexanox shows little therapeutic potential in these tumors
Nadège Dubois, Sharon Berendsen, Aurélie Henry, Minh Nguyen, Vincent Bours, Pierre Alain Robe
Aim: This study aims to analyze the role of I-kappa-B kinase (IKK)-epsilon in glioblastoma (GBM).
Methods: A series of in vitro, in vivo, microarray, and immunohistochem...
Suppressive effect of mesenchymal stromal cells on interferon-γ-producing capability of spleen cells was specifically enhanced through humoral mediator(s) from mouse oral squamous cell carcinoma Sq-1979 Cells In Vitro
Toshihiro Inagaki, Masako Mizuno-Kamiya, Eiji Takayama, Harumi Kawaki, Eiichi Chihara, Yasunori Muramatsu, Shinichiro Sumitomo, Nobuo Kondoh
Aim: The aim of this study was to compare the immunomodulatory effects in the tumor milieu of mouse oral squamous cell carcinoma (OSCC) cells harboring primary and advanced phenotypes. We estab...
An interplay between MicroRNA and SOX4 in the regulation of epithelial–mesenchymal transition and cancer progression
Anjali Geethadevi, Ansul Sharma, Manish Kumar Sharma, Deepak Parashar
MicroRNAs (miRNAs) are abundant class of small, noncoding RNAs which are emerging as a potential therapeutic target for various cancers. Sex-determining region Y-related high-mobility group box 4 (S...
MicroRNAs differentially expressed in prostate cancer of African-American and European-American men
Ernest K Amankwah
African-American (AA) men have higher rates of prostate cancer incidence and mortality compared with European-American (EA) men. Although several socioeconomic and environmental factors may contribu...
The role of reactive oxygen species in screening anticancer agents
Xiaohui Xu, Zilong Dang, Taoli Sun, Shengping Zhang, Hongyan Zhang
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Development of anticancer agents with high efficacy and low toxicity has always been a challenge in cancer therapeutics. Reactive oxygen species (ROS) are one of the most important physiological sti...
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