January-February 2017| Vol 3| Issue 1
Genome-wide transcriptome analysis of prostate cancer tissue identified overexpression of specific members of the human endogenous retrovirus-K family
Aim: Human endogenous retroviruses (HERVs) are integrated into the human genome and represent 8% of the total genome. A retrovirus is the most complete retroelement and is characterized by ...
Clinical utility of interleukin-18 in breast cancer patients: A pilot study
Reecha A Parikh, Toral P Kobawala, Trupti I Trivedi, Mahnaz M Kazi, Nandita R Ghosh
Aim: The aim of this study is to analyze the protein expression of interleukin 18 (IL-18) in patients with untreated breast cancer and further to evaluate its clinical efficacy in predicting tr...
Current and future systemic treatment options for advanced soft-tissue sarcoma beyond anthracyclines and ifosfamide
Nadia Hindi, Javier Martin-Broto
Sarcomas are rare, life-threatening, malignant tumors. Surgery is the cornerstone of therapy in the localized setting. About one-third of patients develop distant metastasis. In the metastatic setting...
The genomic organization and function of IRX1 in tumorigenesis and development
Pengxing Zhang, Hongwei Yang, Xin Wang, Liang Wang, Yingduan Cheng, Yongsheng Zhang, Yanyang Tu
Iroquois homeobox (IRX), containing transcription factor family of homologous genes and proteins, is widely expressed in both vertebrates and invertebrates embryonic tissue expression profiles. They p...
Stem cell-based approach in diabetes and pancreatic cancer management
Yi-Zhou Jiang, Demeng Chen
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Stem cell-mediated therapy is a promising strategy for treating pancreatic diseases such as Type-1 diabetes (T1D) and pancreatic cancers. Although islet transplantation has been reported to be an effe...
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