• Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2015  |  Volume : 1  |  Issue : 2  |  Page : 39-42

Monitoring of Disease Activity in Chronic Myeloid Leukemia-chronic Phase Patients Treated with Indian Generic Veenat (NATCO) Imatinib Mesylate: A Tertiary Care Experience

Department of Pathology, Army Hospital Research and Referral, Delhi Cantt., New Delhi, India

Correspondence Address:
Dr. Tathagat Chatterjee
Department of Pathology, Army Hospital Research and Referral, Delhi Cantt., New Delhi 110010
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2395-3977.155919

Rights and Permissions

Aim: Real-time quantitative polymerase chain reaction (RT-PCR) is a sensitive technique to monitor treatment response in chronic myeloid leukemia (CML). Standardization of RT-PCR protocols and interpretation of results are important to maintain the reliability of this molecular test. Methods: We present the analysis of treatment monitoring after administration of Indian generic imatinib mesylate (IM) (Veenat) in 73 patients with CML-chronic phase using RT-PCR. Results: A consistent decrease in the median breakpoint cluster region-abelson1 (BCR-ABL1) percentage denoting a continued time-bound response to IM is observed. At 6 months, 87.5% patients showing ≥ 1-log reduction in BCR-ABL1 levels subsequently developed ≥ 3-log reduction as compared to 42.8% patients showing < 1-log reduction. All patients with ≥ 3-log reduction in BCR-ABL1 at 12 months maintained treatment response at 18 months. Conclusion: The efficacy of Veenat (NATCO) is comparable to Gleevac (Novartis). Patients who attain ≥ 1-log reduction at 6 months and ≥ 2-log reduction at 12 months are more likely to subsequently attain a major molecular response.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded280    
    Comments [Add]    

Recommend this journal