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ORIGINAL ARTICLE
Year : 2015  |  Volume : 1  |  Issue : 2  |  Page : 39-42

Monitoring of Disease Activity in Chronic Myeloid Leukemia-chronic Phase Patients Treated with Indian Generic Veenat (NATCO) Imatinib Mesylate: A Tertiary Care Experience


Department of Pathology, Army Hospital Research and Referral, Delhi Cantt., New Delhi, India

Correspondence Address:
Dr. Tathagat Chatterjee
Department of Pathology, Army Hospital Research and Referral, Delhi Cantt., New Delhi 110010
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-3977.155919

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Aim: Real-time quantitative polymerase chain reaction (RT-PCR) is a sensitive technique to monitor treatment response in chronic myeloid leukemia (CML). Standardization of RT-PCR protocols and interpretation of results are important to maintain the reliability of this molecular test. Methods: We present the analysis of treatment monitoring after administration of Indian generic imatinib mesylate (IM) (Veenat) in 73 patients with CML-chronic phase using RT-PCR. Results: A consistent decrease in the median breakpoint cluster region-abelson1 (BCR-ABL1) percentage denoting a continued time-bound response to IM is observed. At 6 months, 87.5% patients showing ≥ 1-log reduction in BCR-ABL1 levels subsequently developed ≥ 3-log reduction as compared to 42.8% patients showing < 1-log reduction. All patients with ≥ 3-log reduction in BCR-ABL1 at 12 months maintained treatment response at 18 months. Conclusion: The efficacy of Veenat (NATCO) is comparable to Gleevac (Novartis). Patients who attain ≥ 1-log reduction at 6 months and ≥ 2-log reduction at 12 months are more likely to subsequently attain a major molecular response.


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