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REVIEW
Year : 2016  |  Volume : 2  |  Issue : 4  |  Page : 119-124

Metformin in ovarian cancer therapy: A discussion


1 Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
2 School of Life Science and Technology, ShanghaiTech University, Shanghai, China
3 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Correspondence Address:
Jianfeng Guo
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-3977.189306

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Overweight and obesity are dramatically increasing worldwide. In addition to being the most important factor for the increase in diabetes prevalence, there is a growing evidence of obesity being also significantly associated with the risks and poor outcome in ovarian cancer (OVC). Metformin is the most widely used first-line type 2 diabetes drug, currently being studied for its association with the decreased risk of occurrence and better survival of OVC patients. In this review, we discussed the proposed mechanisms of metformin-exerted anticancer effects, as well as the preclinical and clinical data suggesting its beneficial effect against this devastating condition.


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