• Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW
Year : 2016  |  Volume : 2  |  Issue : 5  |  Page : 154-161

Nanoparticle drug delivery systems and three-dimensional cell cultures in cancer treatments and research


1 Key Laboratory of Bio resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China
2 Tissue Engineering Labs, VA Boston Healthcare System, Boston, MA; Department of Orthopedics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Correspondence Address:
Dr. Wanting Niu
Department of Orthopedics, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-3977.192933

Rights and Permissions

Being a great threat to human health, with no permanent cure yet, better treatment and further research in cancer are inevitable. Nanoparticle drug delivery systems (NDDSs), especially pH-sensitive NDDSs, such as lipid-based, polymeric, and mesoporous silica nanoparticles have played a significant role in cancer treatments. Further, three-dimensional (3D) cell cultures models, which include tumor spheroid models, microfluidic systems, and matrix/scaffolds-based 3D tumor, better mimic the tumor microenvironment than the conventional two-dimensional cultures, making it possible to better understand the disease while serving as a useful in vitro model for future research. The present review mainly focuses on such 3D cell cultures and drug delivery systems that are applied in cancer research and treatments.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2732    
    Printed95    
    Emailed0    
    PDF Downloaded566    
    Comments [Add]    
    Cited by others 4    

Recommend this journal