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Year : 2016  |  Volume : 2  |  Issue : 5  |  Page : 154-161

Nanoparticle drug delivery systems and three-dimensional cell cultures in cancer treatments and research

1 Key Laboratory of Bio resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China
2 Tissue Engineering Labs, VA Boston Healthcare System, Boston, MA; Department of Orthopedics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Correspondence Address:
Dr. Wanting Niu
Department of Orthopedics, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2395-3977.192933

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Being a great threat to human health, with no permanent cure yet, better treatment and further research in cancer are inevitable. Nanoparticle drug delivery systems (NDDSs), especially pH-sensitive NDDSs, such as lipid-based, polymeric, and mesoporous silica nanoparticles have played a significant role in cancer treatments. Further, three-dimensional (3D) cell cultures models, which include tumor spheroid models, microfluidic systems, and matrix/scaffolds-based 3D tumor, better mimic the tumor microenvironment than the conventional two-dimensional cultures, making it possible to better understand the disease while serving as a useful in vitro model for future research. The present review mainly focuses on such 3D cell cultures and drug delivery systems that are applied in cancer research and treatments.

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