• Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW
Year : 2017  |  Volume : 3  |  Issue : 5  |  Page : 167-173

Role of exosome microRNA in breast cancer


Department of Medical Oncology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

Correspondence Address:
Ma Fei
Department of Medical Oncology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Panjiayuannanli 17, Chaoyang District, Beijing 100021
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ctm.ctm_14_17

Rights and Permissions

Exosomes are nanovesicles derived from multiple cell types and could be isolated from various bodily fluids, such as blood and saliva. The molecular contents of exosomes have been proved to reflect their parent cell origins. MicroRNA (miRNA), a large family of small, noncoding RNAs, is enriched in exosomes and could regulate the expression of their target genes. Numerous studies have indicated that aberrant expression level of exosomal miRNAs is closely related to the onset of multiple diseases, including cancer. For example, the studies show that tumorigenesis, drug resistance, invasiveness, and metastasis in breast cancer, are partly mediated by exosome miRNAs, functioning as tools for cell-to-cell communication. Furthermore, several investigations have revealed the immense potential of exosome miRNAs to serve as prognostic and diagnostic biomarkers, whereas certain miRNAs could even be on the target list of novel therapies for cancer, including breast cancer. Due to the lack of a standard approach, exosome miRNAs have not been successfully made into clinical practice, yet. In this review, we highlight the major progressions in exosome miRNA research on breast cancer and the current limitations/challenges in its clinical implementation. Promising and potential applications of exosomal miRNAs will also be addressed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed203    
    Printed4    
    Emailed0    
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal