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Year : 2019  |  Volume : 5  |  Issue : 2  |  Page : 37-41

Surface-Enhanced Raman Spectroscopy to study the biological activity of anticancer agent

1 Department of Traditional Chinese Medicine and Chemical Drug, Lanzhou Institutes for Food and Drug Control, Lanzhou, Gansu, China
2 Department of Medicine, The Fifth People's Hospital of Zhuhai, Zhuhai, Guangdong, China
3 Department of Food, Gansu Province Product Quality Supervision and Inspection Research Institute, Lanzhou, Gansu, China
4 Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou, Gansu, China
5 Shanghai Cell Therapy Engineering Research Center, Jiading, Shanghai, China

Correspondence Address:
Dr. Huan Yang
Shanghai Cell Therapy Engineering Research Center, No. 1585, Yuan Guo Road, Jiading District, Shanghai 201805
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ctm.ctm_18_19

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Surface-Enhanced Raman Spectroscopy (SERS) is a sensitive and selective spectroscopic technique for the detection and characterization of analytes, which are adsorbed on suitable metal surfaces. SERS as a strategy has been widely used in detecting target molecules, and the screening of drug activity is mainly to study the biological effects of drug combined with target, so a study on biological activity of anticancer drug based on SERS is a concern to some researchers. SERS combines the advantages of positive identification of molecules in situ, stand-alone detection, well-established instrumentation with high sensitivity, and its noninvasive detection. In this paper, we review on the application of SERS in studying anticancer agent from three aspects, such as studying the effects of anticancer agent on cancer cells, detection of anticancer agent in human plasma, and testing the interaction between anticancer agent and DNA or protein.

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