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Year : 2019  |  Volume : 5  |  Issue : 4  |  Page : 80-82

ABO typing error resolution and transfusion support in a case of an acute leukemia patient showing loss of antigen expression

1 Department of Transfusion Medicine, All India Institute of Medical Science, Bhubaneswar, Odisha, India
2 Department of Transfusion Medicine, SCB Medical College, Cuttack, Odisha, India

Correspondence Address:
Dr. Debasish Mishra
All India Institute of Medical Science, Bhubaneswar, Odisha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ctm.ctm_28_19

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ABO and RhD typing is an essential step before the transfusion of blood components to a patient. ABO blood group system is a significant group, which causes hemolytic transfusion reaction destroying donor red blood cells. Hence, ABO typing error should be resolved before transfusion. Especially acute leukemia patients, there is a loss of A, B, and H antigens. In this group of patients, no reaction was seen in Cell typing/forward grouping typing. An adsorption-elution study is required to support the correct blood type. Response with anti-A1, anti-AB, and anti-H in red cell typing and saliva testing is necessary to distinguish between different weak A subgroups. We presented a case of loss of A antigens and transfusion support to a leukemia patient for initiation of chemotherapy.

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