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   Table of Contents - Current issue
July-September 2019
Volume 5 | Issue 3
Page Nos. 47-63

Online since Monday, September 30, 2019

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OSMCC: An online survival analysis tool for Merkel cell carcinoma p. 47
Umair Ali Khan Saddozai, Qiang Wang, Xiaoxiao Sun, Yifang Dang, JiaJia Lv, Junfang Xin, Wan Zhu, Yongqiang Li, Xinying Ji, Xiangqian Guo
Aims: To develop a free accessible online tool to identify the prognostic markers for Merkel cell carcinoma (MCC) and to estimate the significance of interested gene in a cohort of clinical patients. Settings and Design: R package is used to calculate and plot the Kaplan–Meier survival curve. Subjects and Methods: An online search engine was developed by combining MCC datasets with available anatomoclinical data in Gene Expression Omnibus. In current study, genomic expression profile of thirty patients comprising 42985 probes and 21651 genes was evaluated. Patients were divided into first quartile, second quartile, and third quartile. Information about different cancer patients of varying stages (Stage I–IV) was stored using median survival scale of 14.5 months. Data were stored in SQL Server database and hosted on Windows Server 2008 using Apache Tomcat application server. Statistical Analysis Used: Log-rank test was applied and P < 0.05 was considered statistically significant. Results: An Online Survival analysis tool for MCC abbreviating as OSMCC was developed, which can assess the expression level relevance of various genes on the clinical outcome in MCC patients. By OSMCC, the survival curve could be displayed, and the hazard ratio with 95% confidence intervals and log-rank P value can also be calculated. Conclusions: The study demonstrated the ability of OSMCC to identify and analyze transcriptome and clinical datasets for MCC through prognosis significance analysis. So far, OSMCC is the first advanced and specific tool for the prognostic measurement of MCC. Furthermore, OSMCC can prove to be a highly valuable database for the preliminary assessment and identification of potential MCC prognostic biomarkers. OSMCC is accessible at http://bioinfo.henu.edu.cn/MCC/MCCList.jsp.
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Protective activity of selenium against 5-fluorouracil-induced nephrotoxicity in rats p. 50
Elias Adikwu, Nelson Clemente Ebinyo, Beauty Tokoni Amgbare
Background: The nephrotoxic effect of 5-fluorouracil (5-FU) involves alterations in renal function markers and kidney morphology. This study assessed the protective effect of selenium (Se) on 5-FU-induced alterations in renal function markers and kidney morphology in albino rats. Materials and Methods: Forty adult albino rats of (n = 5) used were randomly grouped. Groups B-D received 0.125 mg/kg, 0.25 mg/kg and 0.50 mg/kg of Se intraperitoneally (ip) daily for 5 days, respectively. Group E received 20 mg/kg of 5-FU ip daily for 5 days. Groups F-H received 0.125 mg/kg, 0.25 mg/kg, and 0.5 mg/kg of Se before receiving 20 mg/kg of 5-FU ip daily for 5 days, respectively. Group A (Control) received 0.2 mL of normal saline ip daily for 5 days. Rats were sacrificed on the 6th day, and blood samples were collected and evaluated for markers of serum renal function. Kidneys were assessed for oxidative stress indices and histology. Results: The nephrotoxic effect of 5-FU was characterized by statistically significant (P < 0.001) elevations in creatinine, urea, uric acid, and malondialdehyde levels in comparison to control. Furthermore, significant (P < 0.001) decreases in potassium, sodium, chloride, bicarbonate, glutathione (GSH), catalase, superoxide dismutase, and GSH peroxidase levels were obtained in 5-FU-treated rats in comparison to control. Necroses of kidney tubular epithelial cells and atrophic glomeruli were observed in rats administered with 5-FU. However, 5-FU-induced nephrotoxic changes were significantly downregulated in a dose-dependent fashion in rats supplemented with 0.125 mg/kg (P < 0.05), 0.25 mg/kg (P < 0.01), and 0.50 mg/kg (P < 0.001) of Se when compared to 5-FU treated rats. Conclusion: Supplementation with Se may have clinical benefit in nephrotoxicity caused by 5-FU.
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Advances on the components of fibrinolytic system in malignant tumors p. 56
Zengzheng Ge, Xiaoyan Xu, Zengyu Ge, Shaopeng Zhou, Xiulin Li, Kai Yao, Lan Deng
The major function of fibrinolytic system is to dissolve the fibrins formed by blood coagulation and maintain the balance between blood coagulation and thrombolysis, which plays an important role in maintaining the liquid state of the blood and unclogging the blood vessels. It is a serious problem that malignant tumor does great harm to human life and health. In recent years, more and more studies signified that the fibrinolytic system in malignant tumors, especially adenocarcinoma, plays a major role in its progression, which indicates that the fibrinolytic system is of great significance in the development of malignant tumors. Besides, the fibrinolytic system has also gradually been known and used to diagnose and treat the adenocarcinoma. This article reviews how the fibrinolytic system works in the occurrence of malignant tumor and summarizes the diagnostic method and treatment of adenocarcinoma according to the latest clinical research progress, laying the foundation for further research.
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A patient with persistent foot swelling after ankle sprain: B-Cell lymphoblastic lymphoma mimicking soft-tissue sarcoma p. 60
Crystal R Montgomery-Goecker, Andrew A Martin, Charles F Timmons, Dinesh Rakheja, Veena Rajaram, Hung S Luu
We describe a case of B-cell lymphoblastic lymphoma with an unusual clinical presentation. A 15-year old male with no significant past medical history presented with persistent foot swelling after an ankle sprain. Imaging revealed a mass in the right foot, which was resected and revealed a diffuse infiltrate of B-lymphoblasts. Peripheral blood and bone marrow examinations revealed no abnormalities. These findings were consistent with B-cell lymphoblastic lymphoma, which is an uncommon disease, accounting for only 2% of lymphomas. This case is a reminder that hematolymphoid malignancies can have presentations that mimic sarcomas with no visible peripheral blood or bone marrow involvement. In addition to describing the clinical and histologic features of this case, we also discuss the challenges that can be encountered when establishing a diagnosis of B lymphoblastic lymphoma
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